A prospective, multicenter, open-label assessment of atomoxetine in non-North American children and adolescents with ADHD
Identifieur interne : 00AE04 ( Main/Exploration ); précédent : 00AE03; suivant : 00AE05A prospective, multicenter, open-label assessment of atomoxetine in non-North American children and adolescents with ADHD
Auteurs : Jan K. Buitelaar [Pays-Bas] ; Marina Danckaerts [Belgique] ; Christopher Gillberg [Suède] ; Alessandro Zuddas [Italie] ; Katja Becker [Allemagne] ; Manuel Bouvard [France] ; Jenny Fagan [Afrique du Sud] ; Julia Gadoros [Hongrie] ; Valerie Harpin [Royaume-Uni] ; Philip Hazell [Australie] ; Mats Johnson [Suède] ; Tally Lerman-Sagie [Israël] ; Cesar A. Soutullo [Espagne] ; Tomasz Wolanczyk [Pologne] ; Pal Zeiner [Norvège] ; Daniel S. Fouche [États-Unis, Pays-Bas] ; Judith Krikke-Workel [États-Unis, Pays-Bas] ; Shuyu Zhang [États-Unis, Pays-Bas] ; David Michelson [États-Unis, Pays-Bas]Source :
- European child & adolescent psychiatry [ 1018-8827 ] ; 2004.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Enfant.
English descriptors
- KwdEn :
Abstract
Objective The aim of this study was to study treatment response to atomoxetine in a large, multicenter study of non-North American patients with ADHD. Methods A total of 604 children and adolescents with ADHD were enrolled in a 10-week open-label trial with atomoxetine prior to randomization to a double-blind relapse prevention phase at 33 sites in the United Kingdom, continental Europe, Israel, South Africa, and Australia. All patients had ADHD symptom severity at least 1.5 standard deviations above United States age and gender norms for their diagnostic subtype as measured by the investigator-scored ADHD Rating Scale (ADHD RS). Outcomes were assessed by analysis of change in the ADHD RS; functional and psychosocial outcomes were assessed using the Child Health Questionnaire (CHQ). Results At endpoint, ADHD RS total scores decreased by an average of 56.7 %, and 69 % of patients were rated as having no or minimal symptoms. Significant improvement was observed in psychosocial and functional outcomes. Discontinuations attributed to adverse events were < 4 %. Conclusion These open-label data, gathered in an international setting, add to our knowledge of the value of atomoxetine in treating ADHD symptoms, as well as its safety and tolerability.
Affiliations:
- Afrique du Sud, Allemagne, Australie, Belgique, Espagne, France, Hongrie, Israël, Italie, Norvège, Pays-Bas, Pologne, Royaume-Uni, Suède, États-Unis
- Aquitaine, Communauté forale de Navarre, Hongrie centrale, Nouvelle-Aquitaine, Province du Brabant flamand, Østlandet
- Budapest, Louvain, Oslo
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Buitelaar</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, University Medical Center Nijmegen, PO Box 9101</s1><s2>6500 HB Nijmegen</s2><s3>NLD</s3><sZ>1 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>6500 HB Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Danckaerts, Marina" sort="Danckaerts, Marina" uniqKey="Danckaerts M" first="Marina" last="Danckaerts">Marina Danckaerts</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Dienst Kinderpsychiatrie, UZ Gasthuisberg, Herestraat 49</s1><s2>3000 Leuven</s2><s3>BEL</s3><sZ>2 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Gillberg, Christopher" sort="Gillberg, Christopher" uniqKey="Gillberg C" first="Christopher" last="Gillberg">Christopher Gillberg</name><affiliation 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aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Sheffield, S10 5DD</wicri:noRegion></affiliation></author><author><name sortKey="Hazell, Philip" sort="Hazell, Philip" uniqKey="Hazell P" first="Philip" last="Hazell">Philip Hazell</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Child & Youth Mental Health Service, Wallsend Hospital, Longworth Road</s1><s2>Wallsend NSW 2287</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Wallsend NSW 2287</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Mats" sort="Johnson, Mats" uniqKey="Johnson M" first="Mats" last="Johnson">Mats Johnson</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dept. of Child and Adolescent Psychiatry, University of Goteborg, Kungsgatan 12</s1><s2>41119 Goteborg</s2><s3>SWE</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>41119 Goteborg</wicri:noRegion></affiliation></author><author><name 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Wolfson Medical Center</s1><s2>Holon 58100</s2><s3>ISR</s3><sZ>12 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Holon 58100</wicri:noRegion></affiliation></author><author><name sortKey="Soutullo, Cesar A" sort="Soutullo, Cesar A" uniqKey="Soutullo C" first="Cesar A." last="Soutullo">Cesar A. Soutullo</name><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Dept. of Psychiatry & Medical Psychology, University of Navarra</s1><s2>31008 Pamplona</s2><s3>ESP</s3><sZ>13 aut.</sZ></inist:fA14><country>Espagne</country><placeName><region nuts="2" type="communauté">Communauté forale de Navarre</region></placeName></affiliation></author><author><name sortKey="Wolanczyk, Tomasz" sort="Wolanczyk, Tomasz" uniqKey="Wolanczyk T" first="Tomasz" last="Wolanczyk">Tomasz Wolanczyk</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Dpto. Klinika Psychiatrii Dzieciecej, AM w Warszawie, ul. 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Fouche</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Lilly Research Laboratories</s1><s2>Indianapolis, Indiana 46285</s2><s3>USA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Lilly Research Laboratories</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Psychiatry & Academic, Center for Child and Adolescent Psychiatry, University Medical Center St. Radbond (Internal Post 333)</s1><s2>6500 HB Nijmegen</s2><s3>NLD</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>6500 HB Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Krikke Workel, Judith" sort="Krikke Workel, Judith" uniqKey="Krikke Workel J" first="Judith" last="Krikke-Workel">Judith Krikke-Workel</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Lilly Research Laboratories</s1><s2>Indianapolis, Indiana 46285</s2><s3>USA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Lilly Research Laboratories</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Psychiatry & Academic, Center for Child and Adolescent Psychiatry, University Medical Center St. Radbond (Internal Post 333)</s1><s2>6500 HB Nijmegen</s2><s3>NLD</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>6500 HB Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Shuyu" sort="Zhang, Shuyu" uniqKey="Zhang S" first="Shuyu" last="Zhang">Shuyu Zhang</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Lilly Research Laboratories</s1><s2>Indianapolis, Indiana 46285</s2><s3>USA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Lilly Research Laboratories</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Psychiatry & Academic, Center for Child and Adolescent Psychiatry, University Medical Center St. Radbond (Internal Post 333)</s1><s2>6500 HB Nijmegen</s2><s3>NLD</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>6500 HB Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Michelson, David" sort="Michelson, David" uniqKey="Michelson D" first="David" last="Michelson">David Michelson</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Lilly Research Laboratories</s1><s2>Indianapolis, Indiana 46285</s2><s3>USA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Lilly Research Laboratories</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Psychiatry & Academic, Center for Child and Adolescent Psychiatry, University Medical Center St. Radbond (Internal Post 333)</s1><s2>6500 HB Nijmegen</s2><s3>NLD</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>6500 HB Nijmegen</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">04-0603761</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 04-0603761 INIST</idno><idno type="RBID">Pascal:04-0603761</idno><idno type="wicri:Area/PascalFrancis/Corpus">004C15</idno><idno type="wicri:Area/PascalFrancis/Curation">001499</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">004D00</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">004D00</idno><idno type="wicri:doubleKey">1018-8827:2004:Buitelaar J:a:prospective:multicenter</idno><idno type="wicri:Area/Main/Merge">00BB27</idno><idno type="wicri:Area/Main/Curation">00AE04</idno><idno type="wicri:Area/Main/Exploration">00AE04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A prospective, multicenter, open-label assessment of atomoxetine in non-North American children and adolescents with ADHD</title><author><name sortKey="Buitelaar, Jan K" sort="Buitelaar, Jan K" uniqKey="Buitelaar J" first="Jan K." last="Buitelaar">Jan K. Buitelaar</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, University Medical Center Nijmegen, PO Box 9101</s1><s2>6500 HB Nijmegen</s2><s3>NLD</s3><sZ>1 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>6500 HB Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Danckaerts, Marina" sort="Danckaerts, Marina" uniqKey="Danckaerts M" first="Marina" last="Danckaerts">Marina Danckaerts</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Dienst Kinderpsychiatrie, UZ Gasthuisberg, Herestraat 49</s1><s2>3000 Leuven</s2><s3>BEL</s3><sZ>2 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Gillberg, Christopher" sort="Gillberg, Christopher" uniqKey="Gillberg C" first="Christopher" last="Gillberg">Christopher Gillberg</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dept. of Child and Adolescent Psychiatry, University of Goteborg, Kungsgatan 12</s1><s2>41119 Goteborg</s2><s3>SWE</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>41119 Goteborg</wicri:noRegion></affiliation></author><author><name sortKey="Zuddas, Alessandro" sort="Zuddas, Alessandro" uniqKey="Zuddas A" first="Alessandro" last="Zuddas">Alessandro Zuddas</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Child NeuroPsychiatry, Department of Neuroscience, University of Cagliari, Via Ospedale 119</s1><s2>09124 Cagliari</s2><s3>ITA</s3><sZ>4 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>09124 Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Becker, Katja" sort="Becker, Katja" uniqKey="Becker K" first="Katja" last="Becker">Katja Becker</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Central Institut for Mental Health, Dept. of Child and Adolescent Psychiatry, J5</s1><s2>68072 Mannheim</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>68072 Mannheim</wicri:noRegion><wicri:noRegion>J5</wicri:noRegion><wicri:noRegion>68072 Mannheim</wicri:noRegion></affiliation></author><author><name sortKey="Bouvard, Manuel" sort="Bouvard, Manuel" uniqKey="Bouvard M" first="Manuel" last="Bouvard">Manuel Bouvard</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Centre Hospitalier Charles Perrens, Service de Psychiatrie de l'Enfant et de l'Adolescent, 121 Rue De La Bechade</s1><s2>Bordeaux 33076</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName></affiliation></author><author><name sortKey="Fagan, Jenny" sort="Fagan, Jenny" uniqKey="Fagan J" first="Jenny" last="Fagan">Jenny Fagan</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Child Psychiatry, US Medical School, Francie van Zijl drive, Parow 7500</s1><s2>Capetown</s2><s3>ZAF</s3><sZ>7 aut.</sZ></inist:fA14><country>Afrique du Sud</country><wicri:noRegion>Capetown</wicri:noRegion></affiliation></author><author><name sortKey="Gadoros, Julia" sort="Gadoros, Julia" uniqKey="Gadoros J" first="Julia" last="Gadoros">Julia Gadoros</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Alapitvany a "Gyermek lelki egeszsegeert", Vadaskert Korhaz es Szakambulancia</s1><s2>1021 Budapest</s2><s3>HUN</s3><sZ>8 aut.</sZ></inist:fA14><country>Hongrie</country><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Harpin, Valerie" sort="Harpin, Valerie" uniqKey="Harpin V" first="Valerie" last="Harpin">Valerie Harpin</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Ryegate Children's Centre, Tapton Crescent Road</s1><s2>Sheffield, S10 5DD</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Sheffield, S10 5DD</wicri:noRegion></affiliation></author><author><name sortKey="Hazell, Philip" sort="Hazell, Philip" uniqKey="Hazell P" first="Philip" last="Hazell">Philip Hazell</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Child & Youth Mental Health Service, Wallsend Hospital, Longworth Road</s1><s2>Wallsend NSW 2287</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Wallsend NSW 2287</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Mats" sort="Johnson, Mats" uniqKey="Johnson M" first="Mats" last="Johnson">Mats Johnson</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dept. of Child and Adolescent Psychiatry, University of Goteborg, Kungsgatan 12</s1><s2>41119 Goteborg</s2><s3>SWE</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>41119 Goteborg</wicri:noRegion></affiliation></author><author><name sortKey="Lerman Sagie, Tally" sort="Lerman Sagie, Tally" uniqKey="Lerman Sagie T" first="Tally" last="Lerman-Sagie">Tally Lerman-Sagie</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Pediatric Neurology Unit, E. Wolfson Medical Center</s1><s2>Holon 58100</s2><s3>ISR</s3><sZ>12 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Holon 58100</wicri:noRegion></affiliation></author><author><name sortKey="Soutullo, Cesar A" sort="Soutullo, Cesar A" uniqKey="Soutullo C" first="Cesar A." last="Soutullo">Cesar A. Soutullo</name><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Dept. of Psychiatry & Medical Psychology, University of Navarra</s1><s2>31008 Pamplona</s2><s3>ESP</s3><sZ>13 aut.</sZ></inist:fA14><country>Espagne</country><placeName><region nuts="2" type="communauté">Communauté forale de Navarre</region></placeName></affiliation></author><author><name sortKey="Wolanczyk, Tomasz" sort="Wolanczyk, Tomasz" uniqKey="Wolanczyk T" first="Tomasz" last="Wolanczyk">Tomasz Wolanczyk</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Dpto. Klinika Psychiatrii Dzieciecej, AM w Warszawie, ul. Marszalkowska 24</s1><s2>00-576 Warszawa</s2><s3>POL</s3><sZ>14 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>00-576 Warszawa</wicri:noRegion></affiliation></author><author><name sortKey="Zeiner, Pal" sort="Zeiner, Pal" uniqKey="Zeiner P" first="Pal" last="Zeiner">Pal Zeiner</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Senter for barne - og ungdomspsykiatri, Sognsvannsveien 53/67, PO Box 26</s1><s2>0319 Oslo</s2><s3>NOR</s3><sZ>15 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Fouche, Daniel S" sort="Fouche, Daniel S" uniqKey="Fouche D" first="Daniel S." last="Fouche">Daniel S. Fouche</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Lilly Research Laboratories</s1><s2>Indianapolis, Indiana 46285</s2><s3>USA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Lilly Research Laboratories</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Psychiatry & Academic, Center for Child and Adolescent Psychiatry, University Medical Center St. Radbond (Internal Post 333)</s1><s2>6500 HB Nijmegen</s2><s3>NLD</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>6500 HB Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Krikke Workel, Judith" sort="Krikke Workel, Judith" uniqKey="Krikke Workel J" first="Judith" last="Krikke-Workel">Judith Krikke-Workel</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Lilly Research Laboratories</s1><s2>Indianapolis, Indiana 46285</s2><s3>USA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Lilly Research Laboratories</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Psychiatry & Academic, Center for Child and Adolescent Psychiatry, University Medical Center St. Radbond (Internal Post 333)</s1><s2>6500 HB Nijmegen</s2><s3>NLD</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>6500 HB Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Shuyu" sort="Zhang, Shuyu" uniqKey="Zhang S" first="Shuyu" last="Zhang">Shuyu Zhang</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Lilly Research Laboratories</s1><s2>Indianapolis, Indiana 46285</s2><s3>USA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Lilly Research Laboratories</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Psychiatry & Academic, Center for Child and Adolescent Psychiatry, University Medical Center St. Radbond (Internal Post 333)</s1><s2>6500 HB Nijmegen</s2><s3>NLD</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>6500 HB Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Michelson, David" sort="Michelson, David" uniqKey="Michelson D" first="David" last="Michelson">David Michelson</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Lilly Research Laboratories</s1><s2>Indianapolis, Indiana 46285</s2><s3>USA</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Lilly Research Laboratories</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Psychiatry & Academic, Center for Child and Adolescent Psychiatry, University Medical Center St. Radbond (Internal Post 333)</s1><s2>6500 HB Nijmegen</s2><s3>NLD</s3><sZ>16 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>6500 HB Nijmegen</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">European child & adolescent psychiatry</title><title level="j" type="abbreviated">Eur. child adolesc. psychiatry</title><idno type="ISSN">1018-8827</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">European child & adolescent psychiatry</title><title level="j" type="abbreviated">Eur. child adolesc. psychiatry</title><idno type="ISSN">1018-8827</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Atomoxetine</term><term>Attentional disorder</term><term>Behavioral disorder</term><term>Chemotherapy</term><term>Child</term><term>Concomitant disease</term><term>Hyperactivity</term><term>Mental disorder</term><term>Treatment efficiency</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Trouble attention</term><term>Hyperactivité</term><term>Efficacité traitement</term><term>Atomoxétine</term><term>Chimiothérapie</term><term>Association morbide</term><term>Trouble comportement</term><term>Trouble psychiatrique</term><term>Enfant</term><term>Adolescent</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective The aim of this study was to study treatment response to atomoxetine in a large, multicenter study of non-North American patients with ADHD. Methods A total of 604 children and adolescents with ADHD were enrolled in a 10-week open-label trial with atomoxetine prior to randomization to a double-blind relapse prevention phase at 33 sites in the United Kingdom, continental Europe, Israel, South Africa, and Australia. All patients had ADHD symptom severity at least 1.5 standard deviations above United States age and gender norms for their diagnostic subtype as measured by the investigator-scored ADHD Rating Scale (ADHD RS). Outcomes were assessed by analysis of change in the ADHD RS; functional and psychosocial outcomes were assessed using the Child Health Questionnaire (CHQ). Results At endpoint, ADHD RS total scores decreased by an average of 56.7 %, and 69 % of patients were rated as having no or minimal symptoms. Significant improvement was observed in psychosocial and functional outcomes. Discontinuations attributed to adverse events were < 4 %. Conclusion These open-label data, gathered in an international setting, add to our knowledge of the value of atomoxetine in treating ADHD symptoms, as well as its safety and tolerability.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Espagne</li><li>France</li><li>Hongrie</li><li>Israël</li><li>Italie</li><li>Norvège</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Aquitaine</li><li>Communauté forale de Navarre</li><li>Hongrie centrale</li><li>Nouvelle-Aquitaine</li><li>Province du Brabant flamand</li><li>Østlandet</li></region><settlement><li>Budapest</li><li>Louvain</li><li>Oslo</li></settlement></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Buitelaar, Jan K" sort="Buitelaar, Jan K" uniqKey="Buitelaar J" first="Jan K." last="Buitelaar">Jan K. Buitelaar</name></noRegion><name sortKey="Fouche, Daniel S" sort="Fouche, Daniel S" uniqKey="Fouche D" first="Daniel S." last="Fouche">Daniel S. Fouche</name><name sortKey="Krikke Workel, Judith" sort="Krikke Workel, Judith" uniqKey="Krikke Workel J" first="Judith" last="Krikke-Workel">Judith Krikke-Workel</name><name sortKey="Michelson, David" sort="Michelson, David" uniqKey="Michelson D" first="David" last="Michelson">David Michelson</name><name sortKey="Zhang, Shuyu" sort="Zhang, Shuyu" uniqKey="Zhang S" first="Shuyu" last="Zhang">Shuyu Zhang</name></country><country name="Belgique"><region name="Province du Brabant flamand"><name sortKey="Danckaerts, Marina" sort="Danckaerts, Marina" uniqKey="Danckaerts M" first="Marina" last="Danckaerts">Marina Danckaerts</name></region></country><country name="Suède"><noRegion><name sortKey="Gillberg, Christopher" sort="Gillberg, Christopher" uniqKey="Gillberg C" first="Christopher" last="Gillberg">Christopher Gillberg</name></noRegion><name sortKey="Johnson, Mats" sort="Johnson, Mats" uniqKey="Johnson M" first="Mats" last="Johnson">Mats Johnson</name></country><country name="Italie"><noRegion><name sortKey="Zuddas, Alessandro" sort="Zuddas, Alessandro" uniqKey="Zuddas A" first="Alessandro" last="Zuddas">Alessandro Zuddas</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Becker, Katja" sort="Becker, Katja" uniqKey="Becker K" first="Katja" last="Becker">Katja Becker</name></noRegion></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Bouvard, Manuel" sort="Bouvard, Manuel" uniqKey="Bouvard M" first="Manuel" last="Bouvard">Manuel Bouvard</name></region></country><country name="Afrique du Sud"><noRegion><name sortKey="Fagan, Jenny" sort="Fagan, Jenny" uniqKey="Fagan J" first="Jenny" last="Fagan">Jenny Fagan</name></noRegion></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Gadoros, Julia" sort="Gadoros, Julia" uniqKey="Gadoros J" first="Julia" last="Gadoros">Julia Gadoros</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Harpin, Valerie" sort="Harpin, Valerie" uniqKey="Harpin V" first="Valerie" last="Harpin">Valerie Harpin</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Hazell, Philip" sort="Hazell, Philip" uniqKey="Hazell P" first="Philip" last="Hazell">Philip Hazell</name></noRegion></country><country name="Israël"><noRegion><name sortKey="Lerman Sagie, Tally" sort="Lerman Sagie, Tally" uniqKey="Lerman Sagie T" first="Tally" last="Lerman-Sagie">Tally Lerman-Sagie</name></noRegion></country><country name="Espagne"><region name="Communauté forale de Navarre"><name sortKey="Soutullo, Cesar A" sort="Soutullo, Cesar A" uniqKey="Soutullo C" first="Cesar A." last="Soutullo">Cesar A. Soutullo</name></region></country><country name="Pologne"><noRegion><name sortKey="Wolanczyk, Tomasz" sort="Wolanczyk, Tomasz" uniqKey="Wolanczyk T" first="Tomasz" last="Wolanczyk">Tomasz Wolanczyk</name></noRegion></country><country name="Norvège"><region name="Østlandet"><name sortKey="Zeiner, Pal" sort="Zeiner, Pal" uniqKey="Zeiner P" first="Pal" last="Zeiner">Pal Zeiner</name></region></country><country name="États-Unis"><noRegion><name sortKey="Fouche, Daniel S" sort="Fouche, Daniel S" uniqKey="Fouche D" first="Daniel S." last="Fouche">Daniel S. Fouche</name></noRegion><name sortKey="Krikke Workel, Judith" sort="Krikke Workel, Judith" uniqKey="Krikke Workel J" first="Judith" last="Krikke-Workel">Judith Krikke-Workel</name><name sortKey="Michelson, David" sort="Michelson, David" uniqKey="Michelson D" first="David" last="Michelson">David Michelson</name><name sortKey="Zhang, Shuyu" sort="Zhang, Shuyu" uniqKey="Zhang S" first="Shuyu" last="Zhang">Shuyu Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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